{"product_id":"noggin-over-expression-modulates-the-malignant-behavior-of-aml-von-haytham-khoury","title":"Noggin Over-expression Modulates the Malignant Behavior of AML","description":"\u003cp\u003eAcute Myeloid Leukemia is a deadly disease. Although  our knowledge regarding the mechanisms that govern  the leukemic transformation has largely increased  over the last 20 years, much is still to be  discovered. Deciphering these mechanisms is crucial  for better understanding the pathogenesis of this  fatal illness and also for the development of new  strategies for treating it. In the present work, the  author unveils a new mechanism that contributes to  the pathogenesis of this disease. This mechanism is  namely the overexpression of the secreted protein  Noggin. Noggin is an inhibitor of the bone  morphogentic proteins. Noggin overexpression is  shown, in this research, to be a very frequent  molecular event in acute myeloid leukemia leukemia,  leading to abrogation of both the canonical and the  non-canonical bone morphogentic protein pathways.  Furthermore, Noggin increases the proliferation and  the self-renewal of leukemic progenitors and also  protects the leukemic cells against the cytotoxic  effect of the chemotherapy daunorubicin. Indeed,  these findings suggest that Noggin suppression could  be an interesting target for the treatment of acute  myeloid leukemia.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838386188\"\u003e\u003ch3\u003eA BMP Inhibitor Enhances the Self-Renewal Capacity and the Chemotherapy Resistance of AML Cells\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838386188","offer_id":39499106779229,"sku":"9783838386188","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/138475d7-717b-485f-88b3-35407e1e0d12.jpg?v=1769667318","url":"https:\/\/shop.autorenwelt.de\/en\/products\/noggin-over-expression-modulates-the-malignant-behavior-of-aml-von-haytham-khoury","provider":"Autorenwelt Shop","version":"1.0","type":"link"}