{"product_id":"new-chemical-processes-with-bismuthiii-salts-von-rui-miguel-de-aguiar-pinto","title":"New Chemical Processes with Bismuth(III) Salts","description":"\u003cp\u003eThis book describes several new processes using bismuth(III) reagents and catalysts, with application to steroid chemistry. Two processes for the nucleophilic ring opening of epoxysteroids are presented: one describes the Ritter reaction to afford vic-N-acylamino-hydroxy compounds, whereas the other show that bismuth(III) salts can act both as nucleophiles and reaction promoters, to obtain ¿-substituted-hydroxy steroids. The bismuth(III) salt-catalyzed rearrangement of epoxysteroids is described as a strategy to obtain steroids bearing abnormal ring fusions, inverted configuration at bridgehead stereocenters and methyl groups out of their typical positions, leading to olefinic 19-nor, 18,19-dinor- or 18-norsteroids. The bismuth(III) triflate-catalyzed cleavage of the C17-side chain of corticosteroid allows the easy preparation of highly functionalized 17-ketosteroids. Moreover, full structural elucidation of all the obtained compounds is provided and largely discussed. A general introduction provides the background knowledge to this work. The concept of pharmaceutical green chemistry is discussed in the light of its integration with chemical process within pharmaceutical chemistry.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783846543931\"\u003e\u003ch3\u003eApplications of Bismuth(III) Reagents and Catalysts to the Chemistry of Steroid Compounds\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783846543931","offer_id":39494596165725,"sku":"9783846543931","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a348b12e-378d-4314-9b2b-9df81f83d01a.jpg?v=1756184795","url":"https:\/\/shop.autorenwelt.de\/en\/products\/new-chemical-processes-with-bismuthiii-salts-von-rui-miguel-de-aguiar-pinto","provider":"Autorenwelt Shop","version":"1.0","type":"link"}