{"product_id":"natural-antioxidants-an-approach-towards-tuberculosis-management-von-zeeshan-fatima","title":"Natural Antioxidants: An Approach Towards Tuberculosis Management","description":"\u003cp\u003eTuberculosis (TB) has been reported to have fifth  highest fatality rate in the world, a disease  claiming between 2 and 3 million lives a year. One  of the important reasons why this killer parasite is  spiraling out of control at an alarming rate is  attributed to the prevalence of multidrug-resistant  (MDR) strains and emergence of AIDS-related TB.  Focus has now been shifted towards development of  compounds from natural sources that have  antimycobacterial activity. The incorporation of  such compounds, like polyphenols namely  Epigallocatechin-3-gallate (EGCG) from green tea, as  the natural component of tuberculosis treatments has  been studied here. Reactive oxygen species and tumor  necrosis factor (TNF-¿) are the hallmarks of  tuberculosis. The augmented expression of TNF-¿ at  both the gene and protein levels in MTB-infected  monocytes is suppressed by EGCG in dose-dependent  manner. Also,EGCG ameliorated the IFN-¿ levels, the  glutathione peroxidase activity, which correlated  inversely with the downregulation of ROS and TNF- ¿  in MTB-infected monocytes. Hence, EGCG may prove to  be a valuable natural antioxidant in tuberculosis  management.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838394329\"\u003e\u003ch3\u003eGreen Tea Polyphenol (EGCG) as Potential Adjunct in Combating Mycobacterium tuberculosis Pathogenesis\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838394329","offer_id":39499021221981,"sku":"9783838394329","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f062e2bd-817b-4e0d-afd8-118724ed889a.jpg?v=1770529191","url":"https:\/\/shop.autorenwelt.de\/en\/products\/natural-antioxidants-an-approach-towards-tuberculosis-management-von-zeeshan-fatima","provider":"Autorenwelt Shop","version":"1.0","type":"link"}