{"product_id":"monoamine-transporter-inhibitors-von-rohan-p-perera","title":"Monoamine Transporter Inhibitors","description":"\u003cp\u003eVesicular monoamine transporters (VMAT) are  responsible for the uptake of cytosolic monoamines  into synaptic vesicles in monoaminergic neurons. In  the central nervous system, vesicular monoamine  transporter 2 (VMAT2) is the only transporter that  moves cytoplasmic dopamine (DA) into synaptic  vesicles.  Pharmacologically enhancing DA sequestration by  VMAT2, and thus preventing the oxidation of DA, may  be a strategy for treating diseases such as Parkinson¿s disease. The neurotoxicity and addictive properties of various psychostimulants have been attributed, at least partly, to their interference with VMAT2 functions. Therefore, VMAT2 may also be a novel target for the development of treatments for  psychostimulant abuse. This book summarizes the  possible role of VMAT2 as a therapeutic target and  the current understanding of the structure-activity  relationship of ligands, including tetrabenazine  analogs, ketanserin analogs, and  3-amine-2- phenylpropene  with VMAT. The molecular structure  of VMAT2 and its relevance to ligand binding and  the mechanism of transport of these compounds  through VMAT are briefly discussed in this book.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838375953\"\u003e\u003ch3\u003eNovel Target for Drug Development\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838375953","offer_id":39469283442781,"sku":"9783838375953","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e50ce9b9-5c35-4fd4-92b3-7b5333fa0f70.jpg?v=1774682139","url":"https:\/\/shop.autorenwelt.de\/en\/products\/monoamine-transporter-inhibitors-von-rohan-p-perera","provider":"Autorenwelt Shop","version":"1.0","type":"link"}