{"product_id":"modified-neldermead-simplex-method-for-clustering-gene-expression-data-von-pandi-malaisamy","title":"Modified Neldermead Simplex Method for Clustering Gene Expression Data","description":"\u003cp\u003eIn many numerical tests, Nelder-Mead (NM) method succeeds in obtaining a good reduction in the function value using a relatively small number of function evaluations. Generally, the microarray gene expression data dimension is high. However, when optimizing high dimensional problems, Nelder-Mead method suffers from poor convergence rate and early restart. To overcome this problem and to increase the global search area, the Modified Nelder-Mead (MNM) is proposed. In the proposed work, the expansion step is replaced by a new step called spread out. It is processed based on the assumption that a better point will be available apart from the best and good point. This may increase the global search considerably and will result in a better solution.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786202024303\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786202024303","offer_id":39447645880413,"sku":"9786202024303","price":35.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/50e7f678-3f16-4711-9aac-7bdafe63b0a8.jpg?v=1773730956","url":"https:\/\/shop.autorenwelt.de\/en\/products\/modified-neldermead-simplex-method-for-clustering-gene-expression-data-von-pandi-malaisamy","provider":"Autorenwelt Shop","version":"1.0","type":"link"}