{"product_id":"micrornas-in-osteosarcomas-von-luisa-montanini","title":"MicroRNAs in osteosarcomas","description":"\u003cp\u003eIn many studies, performed to investigate the genes   and gene products that drive the metastatic process,   it has become evident that, in addition to   alterations in protein-encoding genes, abnormalities   in non-coding genes can also contribute to cancer   pathogenesis. In the context of microRNAs in   tumours, our aim was to evaluate whether pro-  metastatic and non-metastatic sarcoma cells may   differ in their microRNA expression, in the effort   to identify single pro-metastatic microRNAs in bone   and soft-tissue sarcomas. A number of microRNAs   reported in the miRNA registry data base were found   to be differential expressed in MG-63 and 143B   osteosarcoma model cell lines. Two of the   differentially expressed microRNA, miR-93 and miR-  210, for which no functional data were available,   were analyzed in different cell lines and tissues   and investigated for their potential involvement in   motility phenomena. The expression of another set of   four differentially expressed miRNAs (miR-9, miR-  183, miR-196a, miR-484), was identified through a   global expression analysis, and analyzed in surgical   specimens of low- and high-grade osteosarcoma   patients.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843353311\"\u003e\u003ch3\u003eExpression analysis and potential role in tumour progression\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843353311","offer_id":39493618466909,"sku":"9783843353311","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4e0a3cff-cebe-4b1d-926c-466f424ec8e0.jpg?v=1769493952","url":"https:\/\/shop.autorenwelt.de\/en\/products\/micrornas-in-osteosarcomas-von-luisa-montanini","provider":"Autorenwelt Shop","version":"1.0","type":"link"}