{"product_id":"microbubbles-and-ultrasound-von-raniska-tente","title":"Microbubbles and ultrasound","description":"\u003cp\u003eMicrobubbles have been used for several decades as  ultrasound contrast agents in diagnostic ultrasound  imaging. However, their application in gene therapy  as delivery vehicles has only recently been realised.  The presence of microbubbles in close proximity to  cells during ultrasound insonation can increase the  efficacy of drug or gene delivery by inducing  sonoporation. In this research project, experimental  in-house microbubbles were used in order to establish  the exact parameters that lead to sonoporation.  Confocal imaging and 3-D reconstruction indicated the  structure, morphology and size-distribution of these  membrane-bound microbodies. Subsequently, cells were  grown in an acoustically-transparent parallel  membrane environment, where delivery of molecules of  various sizes, in the presence of both in-house and  Definity® microbubbles was investigated. The acoustic  parameters were established for achieving  sonoporation with the aid of a clinically relevant  scanner in the presence of commercially available  Definity® microbubbles.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844301069\"\u003e\u003ch3\u003eAn investigation of microbubble-cell interaction and development of an ultrasound delivery system\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844301069","offer_id":39497136701533,"sku":"9783844301069","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b2a12e1c-4db6-415b-80af-d50cac8767a4.jpg?v=1776054506","url":"https:\/\/shop.autorenwelt.de\/en\/products\/microbubbles-and-ultrasound-von-raniska-tente","provider":"Autorenwelt Shop","version":"1.0","type":"link"}