{"product_id":"medullary-thyroid-carcinoma-von-undefined","title":"Medullary Thyroid Carcinoma","description":"\n                                \n                \u003cp\u003eAfter 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.\u003c\/p\u003e\n                                \n                \n                \u003cp\u003eMedullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective  tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. \u003c\/p\u003e\n                                \n                \n                \u003cp\u003eThis book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.\u003c\/p\u003e\n                            \n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783031803956\"\u003e\u003ch3\u003eBiology, management, and treatment of sporadic and hereditary MTC\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Hardcover - 9783031803956","offer_id":54431934021957,"sku":"9783031803956","price":149.79,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/aae8c223-610a-4969-a8d1-0a2dab183b40.jpg?v=1774156275","url":"https:\/\/shop.autorenwelt.de\/en\/products\/medullary-thyroid-carcinoma-von-undefined","provider":"Autorenwelt Shop","version":"1.0","type":"link"}