{"product_id":"mechanisms-of-polymer-matrix-formation-in-sustained-release-tablets-von-aleksandra-dumicic","title":"Mechanisms of polymer matrix formation in sustained release tablets","description":"\u003cp\u003eAlthough the problem of non-uniform, unpredictable  matrices has been recently recognised, a limited  number of literature reports deals with the problem,  and without providing the mechanistic reasons for  the variability in drug release characteristics.  Identifying and understanding the main factors  affecting the polymer matrix in the tablets is  important to avoid intratablet and intrabatch  variations in drug release rates, providing  better systems in terms of safety\/ efficacy,  minimising risks of unexpected release of high  amounts of drug (dose dumping).  Matrix formation starts with application of force  which brings polymer particles into close contact. At temperatures above polymer glass transition  temperature (Tg), application of force (stress)  leads to a stable matrix as rubbery particles  undergo viscoelastic flow (creep) and coalesce due  to interdiffusion of mobile polymer chains of the  particles in contact.  If the temperature is below or close to polymer Tg,  polymer particles presumably store (lock) some  stresses which can be released on storage above the  matrix Tg, remodelling the matrix and affecting drug  release characteristics.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838331423\"\u003e\u003ch3\u003eEffects on drug release characteristics\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838331423","offer_id":39469195559005,"sku":"9783838331423","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e44969bd-1bde-4166-8742-7247d791f75f.jpg?v=1768976435","url":"https:\/\/shop.autorenwelt.de\/en\/products\/mechanisms-of-polymer-matrix-formation-in-sustained-release-tablets-von-aleksandra-dumicic","provider":"Autorenwelt Shop","version":"1.0","type":"link"}