{"product_id":"limfoproliferatiwnyj-sindrom-s-autoimmunitetom-von-imen-chabchub","title":"Limfoproliferatiwnyj sindrom s autoimmunitetom","description":"\u003cp\u003eAutoimmunnyj limfoproliferatiwnyj sindrom (ALPS) - redkoe nasledstwennoe zabolewanie, kotoroe obychno porazhaet detej i sohranqetsq wo wzroslom wozraste. On harakterizuetsq hronicheskoj dobrokachestwennoj limfoproliferaciej, autoimmunitetom, powyshennym kolichestwom dwazhdy otricatel'nyh T-kletok i powyshennym riskom progressirowaniq do limfomy, chto qwlqetsq sledstwiem perwichnogo defekta apoptoza. Rasprostranennost' ätogo sindroma ostaetsq nedoocenennoj iz-za nespecifichnosti ego klinicheskih priznakow. Na samom dele, u mnogih pacientow s ALPS wmesto ätogo diagnostiruütsq drugie zabolewaniq s razlichnym lecheniem i prognozom. V poslednie gody, blagodarq luchshemu ponimaniü patofiziologicheskih mehanizmow apoptoza i wyqwleniü ego geneticheskih determinant, byl dostignut znachitel'nyj nauchnyj progress, prolozhiwshij put' k bolee celenaprawlennoj terapii. V ätom obzore my opisywaem patofiziologicheskie mehanizmy i äpidemiologicheskie, klinicheskie, biologicheskie, gistologicheskie, geneticheskie, terapewticheskie i äwolücionnye aspekty ALPS.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786204340395\"\u003e\u003ch3\u003eLimfoproliferatiwnyj sindrom\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786204340395","offer_id":39663242641501,"sku":"9786204340395","price":19.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/cfbd27b1-556f-43fd-a6f2-4e16eaef029f.jpg?v=1758003427","url":"https:\/\/shop.autorenwelt.de\/en\/products\/limfoproliferatiwnyj-sindrom-s-autoimmunitetom-von-imen-chabchub","provider":"Autorenwelt Shop","version":"1.0","type":"link"}