{"product_id":"lagrangian-based-characterisation-of-aerated-stirred-tank-reactors-von-ryan-rautenbach","title":"Lagrangian-Based Characterisation of Aerated Stirred Tank Reactors","description":"Industrial-scale bioreactors expose cells to complex and continuously changing hydrodynamic conditions that are difficult to reproduce at laboratory scale. Conventional scale-down approaches are often developed under single-phase conditions and evaluated primarily using mixing times.\n\nThis work combines experiments and validated Lattice-Boltzmann Large-Eddy Simulations to characterise the multiphase hydrodynamics of a 15 m³ mammalian cell culture stirred tank reactor. A Lagrangian, cell-centred perspective is used to quantify the conditions experienced by cells through velocity distributions, circulation times, residence times, and lifelines. Finite-Time Lyapunov Exponent fields additionally reveal coherent flow structures and transport barriers.\n\nThe methodology is applied to evaluate the Single Multi-Compartment Bioreactor as a representative scale-down system. The results show that similarity achieved under single-phase conditions does not necessarily persist during aeration, highlighting the need to incorporate multiphase lifeline metrics into scale-down development and evaluation.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783689525781\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783689525781","offer_id":58782964023621,"sku":"9783689525781","price":76.5,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/73461_f036438b-6482-4884-99f8-9041f3fcc496.jpg?v=1786164930","url":"https:\/\/shop.autorenwelt.de\/en\/products\/lagrangian-based-characterisation-of-aerated-stirred-tank-reactors-von-ryan-rautenbach","provider":"Autorenwelt Shop","version":"1.0","type":"link"}