{"product_id":"ion-channel-reconstitution-von-c-miller-hrsg","title":"Ion Channel Reconstitution","description":"\u003cp\u003eIt is now over 30 years since the idea of ion-conducting pores burst on the elec­ trophysiological scene, 15 years since these were generalIy realized to be mem­ brane-spanning proteins, and 10 years since the first observations of single ion channels from higher organisms were made. During the past 5 years, several integral membrane channel proteins have been purified in a functionalIy competent state: the nicotinic acetylcholine receptor, the Na + channel, mitochondrial \"VDAC,\" and a variety of porins. The stage is thus set to attack ion channels in the same ways that biochemists have been attacking enzymes for decades: isolation folIowed by functional analysis in as simple a system as possible, with a view towards understanding the molecular mechanisms ofthe protein's behavior and how this is related to the underlying molecular structure. This is always a daunting task, alI the more so with ion channels because of our still primitive and scanty understanding of channel structures and because of the difficulty in iso­ lating functionally active channel proteins. In this volume, which can be considered a biochemically slanted companion to Sakmann and Neher's Single-Channel Recording, I have tried to present a view of the current landscape of ion-channel reconstitution. These chapters illustrate not only the different approaches and techniques of the major practitioners of ion­ channel reconstitution but, as importantly, the varied motivations for doing this kind of work.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9781475713633\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9781475713633","offer_id":39414689857629,"sku":"9781475713633","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/ae0d60c9-4c35-454b-9c37-4bb4e6141cb5.jpg?v=1746850286","url":"https:\/\/shop.autorenwelt.de\/en\/products\/ion-channel-reconstitution-von-c-miller-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}