{"product_id":"inhibition-of-therapeutic-protein-aggregation-by-cyclodextrins-von-tim-serno","title":"Inhibition of therapeutic protein aggregation by cyclodextrins","description":"\u003cp\u003eAdvances in molecular genetics and recombinant protein (rDNA) technology lead to an\u003c\/p\u003e\u003cp\u003eincreasing availability of protein-based biomolecules1. In contrast to conventional low\u003c\/p\u003e\u003cp\u003emolecular weight synthetic chemical drugs protein drugs provide a relatively high specifity\u003c\/p\u003e\u003cp\u003eand activity at low concentrations2. Therefore, today protein drugs represent a fast-growing\u003c\/p\u003e\u003cp\u003eclass of therapeutic molecules1,3. Protein-based drugs offer a multitude of new therapeutic\u003c\/p\u003e\u003cp\u003eoptions, mainly for the treatment of severe and chronic diseases such as autoimmune or\u003c\/p\u003e\u003cp\u003ecancer diseases2. However, with the increasing number of ¿new biologic entities¿ passing\u003c\/p\u003e\u003cp\u003ethrough development and manufacturing and finally reaching patients, also unprecedented\u003c\/p\u003e\u003cp\u003echallenges for the design of stable, safe and convenient formulations are encountered4.\u003c\/p\u003e\u003cp\u003eThe first obvious formulation challenge to be faced concerns the delivery of protein drugs.\u003c\/p\u003e\u003cp\u003eOral delivery ¿ which is generally the preferred and most widely applied route of drug\u003c\/p\u003e\u003cp\u003eadministration ¿ is not feasible with protein drugs.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783869556314\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783869556314","offer_id":40131598123101,"sku":"9783869556314","price":40.55,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f60ba010-a546-47e3-a2a2-2c7284eafbfb.jpg?v=1756876997","url":"https:\/\/shop.autorenwelt.de\/en\/products\/inhibition-of-therapeutic-protein-aggregation-by-cyclodextrins-von-tim-serno","provider":"Autorenwelt Shop","version":"1.0","type":"link"}