{"product_id":"i-domains-in-integrins-von-donald-gullberg-hrsg","title":"I Domains in Integrins","description":"In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain. \u003cbr\u003eThis book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9780306478369\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9780306478369","offer_id":51255813702,"sku":"9780306478369","price":160.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/ec58e9cf-cbfa-4f13-b750-8afa8469e181.jpg?v=1761801327","url":"https:\/\/shop.autorenwelt.de\/en\/products\/i-domains-in-integrins-von-donald-gullberg-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}