{"product_id":"genetic-immunization-cytokine-immunomodulation-von-mohammad-ameen-al-aghbar","title":"Genetic Immunization \u0026 Cytokine Immunomodulation","description":"\u003cp\u003eIn chronic parasitic infections, the interplay between the host and the parasite suggests immuno-suppressive mechanisms developed by the parasite. Echinococcus granulosus, a tiny tapeworm that among other helminthes, favors the induction of T helper type 2 responses which are less severe and less destructive than T helper type 1 responses.   This study aimed at exploring the immune response generated in BALB\/c mice using genetic immunization technology. Immuno-modulation by the co-delivery of different cytokine genes (IFN-¿, IL-12, IL-4) was also investigated.   Immunization by antigen B or its second subunit (EgAgB8\/2) revealed dominated T helper type 2 cytokine response, IgG3 humoral response, low splenocyte cell proliferation, and low CD8+ cell count. However, restored CD8+ cell count, high splenocyte cell proliferation, and high expression of IFN-¿ cytokine in IFN-¿ gene co-immunized mice indicates the efficiency of cytokine gene immuno-modulation in skewing the response toward T helper type 1.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783847312390\"\u003e\u003ch3\u003eImmune Response in Mice Genetically Immunized with Echinococcus granulosus AgB2 in Combination with Cytokine Genes\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783847312390","offer_id":39472593371229,"sku":"9783847312390","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f5e3646d-b564-4eea-a3d0-dff16f7742cd.jpg?v=1776321760","url":"https:\/\/shop.autorenwelt.de\/en\/products\/genetic-immunization-cytokine-immunomodulation-von-mohammad-ameen-al-aghbar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}