{"product_id":"gene-transfer-in-the-cardiovascular-system-experimental-approaches-and-therapeutic-implications-von-keith-l-march-hrsg","title":"Gene Transfer in the Cardiovascular System","description":"The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled \"Artificial Self-Assembling Systems for Gene Transfer\", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9780792398592\"\u003e\u003ch3\u003eExperimental Approaches and Therapeutic Implications\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Hardcover - 9780792398592","offer_id":50727384774,"sku":"9780792398592","price":213.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a3c7ad23-bb7e-4ea6-a05a-16da55e83ccb.jpg?v=1771305193","url":"https:\/\/shop.autorenwelt.de\/en\/products\/gene-transfer-in-the-cardiovascular-system-experimental-approaches-and-therapeutic-implications-von-keith-l-march-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}