{"product_id":"gamete-proteomics-von-soren-naaby-hansen","title":"Gamete Proteomics","description":"\u003cp\u003eThis book reviews a series of functional and immunological studies of the human sperm proteome.   Two of the most cited studies originate from the examination of capacitation-induced protein modifications, which led to the cloning and characterisation of two new phospho-regulated cancer-testis antigens, named AKAP3 and CABYR.   AKAP3 is a member of the A kinase anchoring protein-family, which provides spatial and temporal specificity to the cAMP-PKA pathway. In addition to scaffolding PKA, PDE and protein phosphatases, AKAP members also bind proteins that share homology to the RII dimerization\/docking  (R2D2) domain of PKA¿ regulatory subunit.  CABYR likewise interacts with a diverse array of signal tranducer molecules via its SH3-, R2D2-, and proline-rich extension-like domains. AKAP3 and CABYR associate in high molecular weight multi-protein complexes, which appear to regulate the energy supply to and motion of the sperm flagellum. The putative functional role of the CABYR signalling scaffold in cancer cells is discussed.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659243356\"\u003e\u003ch3\u003eAnalysis of the human sperm proteome\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659243356","offer_id":39486406656093,"sku":"9783659243356","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9fe9cdb2-6102-4dab-b557-46a58896dadd.jpg?v=1769492807","url":"https:\/\/shop.autorenwelt.de\/en\/products\/gamete-proteomics-von-soren-naaby-hansen","provider":"Autorenwelt Shop","version":"1.0","type":"link"}