{"product_id":"formulation-and-evaluation-of-an-in-situ-gel-for-ocular-delivery-von-sachinkumar-patil-shitalkumar-patil-amit-jagdale","title":"Formulation and Evaluation of an In Situ Gel for Ocular Delivery","description":"\u003cp\u003eNorfloxacin ophthalmic solution has been shown to be effective ocular infections and may be used in patients with chronic conjunctivitis or ocular irritation. Norfloxacin in-situ gel was prepared using various concentrations of polymers such as Carbopol-940 (0., 0.2, 0.3 0.4and 0.5% w\/v), HPMC- E50LV (1.5 % w\/v), HPMC E4M (0.6 %w\/v) and HPMC K4M (0.5% w\/v) by pH triggered gelling system with an objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy of drug. The prepared in-situ gels were then evaluated for their visual appearance, clarity, pH, drug content analysis, in-vitro gelation (Gelling capacity), rheological studies, sterility testing, textureanalysis and in-vitro drug release studies. It is evident from these studies that, formed polymeric in-situ gels had transparent, clear possessing satisfactory gelling capacity. The developed formulation was light yellow in colour, therapeutically efficacious, stable, non irritant with sustained release of drug.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659461910\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659461910","offer_id":39434159095901,"sku":"9783659461910","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9bb4d284-78d8-4c01-af8f-4ceff3dbecd8.jpg?v=1776055659","url":"https:\/\/shop.autorenwelt.de\/en\/products\/formulation-and-evaluation-of-an-in-situ-gel-for-ocular-delivery-von-sachinkumar-patil-shitalkumar-patil-amit-jagdale","provider":"Autorenwelt Shop","version":"1.0","type":"link"}