{"product_id":"floating-microspheres-von-supriya-muttepawar","title":"Floating microspheres","description":"\u003cp\u003eGastroretentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit systems avoid the ¿all-or-none¿ gastric emptying nature of single unit systems. A type of multi-unit floating ziprasidone HCL Monohydrate microspheres was prepared by the ionotropic gelation method with NaHCO3 as gas-forming agents being used as gas-forming agent and Eudragit L-100 and Eudragit S-100 as polymer. The solution was dropped to 1% CaCl2 solution containing 10% acetic acid for CO2 gas and gel formation. The effects of gas-forming agents on bead size and floating properties were investigated. As gas-forming agents increased, the size and floating properties increased. Bead porosity and volume average pore size, as well as the surface and cross-sectional morphology of the beads were examined with Scanning Electron Microscopy. The micromeritic properties of microspheres were found to be much improved. In-vitro drug release studies were performed and drug release kinetics were evaluated using the linear regression method.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659327278\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659327278","offer_id":39434269687901,"sku":"9783659327278","price":71.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/53246b63-d8a5-4d4d-8b58-6b825de5a4e1.jpg?v=1769236156","url":"https:\/\/shop.autorenwelt.de\/en\/products\/floating-microspheres-von-supriya-muttepawar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}