{"product_id":"exercise-aging-and-bone-tissue-quality-von-nadder-d-sahar","title":"Exercise, Aging and Bone Tissue Quality","description":"\u003cp\u003eFractures are the most frequent health problem  associated with bone and represent a significant  clinical and economic burden.  Fracture risk is most  often assessed through bone mass scans, which  measure bone quantity. However, aging and  interventions like exercise have a greater influence  on fracture risk than variances in mass predict,  indicating that skeletal integrity is affected by  alterations in tissue quality, and not just  quantity. Currently, there is no clear  understanding of how bone tissue quality contributes  to skeletal integrity or how it can be altered by  external influences. This work employed a murine  model to investigate the effects of exercise and  aging on bone at the tissue level and found that  these influences can modulate bone composition, and  consequently tissue-level mechanical competence,  even in pre-existing bone tissue. These findings  challenge conventional theories of bone adaptation  and imply that changes in tissue quality may often  be overlooked because they can occur independently  of changes to bone mass. This work also illustrates  the potential utility in using compositional markers  to supplement diagnosis of fracture risk.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838366425\"\u003e\u003ch3\u003eInvestigating the effects of exercise and aging on bone''s composition and mechanical integrity\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838366425","offer_id":39499028496477,"sku":"9783838366425","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/1196e49b-fe26-485e-8feb-b1affed19e49.jpg?v=1773123465","url":"https:\/\/shop.autorenwelt.de\/en\/products\/exercise-aging-and-bone-tissue-quality-von-nadder-d-sahar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}