{"product_id":"exact-efficient-and-computationally-feasible-inference-von-max-moldovan","title":"Exact, efficient and computationally feasible inference","description":"\u003cp\u003eIn the application of statistical methods to clinical  practice and research, the difficulty of controlling  type I error is well recognized. In general, the  investigator has two choices - either let the actual  type I error exceed the desired nominal level by an  unknown, and sometimes substantial, amount or impose  a restriction for keeping the type I error within the  target nominal value. The former choice will rely on  methods based on large sample approximations, so- called approximate methods, and the latter choice  will involve one of the exact inference procedures.  Approximate methods can, and typically do, lead to  liberal conclusions, while some exact methods are  known to be conservative. In terms of a classical  clinical trial, a liberal conclusion inflicts the  risk of accepting the effectiveness of a treatment  which in fact is ineffective, while conservatism can  lead to the dismissal of an effective treatment. In  the presented study, we introduce a number of exact  and least conservative inference procedures with an  application to clinical trials of various designs.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838319117\"\u003e\u003ch3\u003eApplication to discrete data problems\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838319117","offer_id":39498937892957,"sku":"9783838319117","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/7774cd86-a7b5-4cec-b751-68afedcbba16.jpg?v=1774935579","url":"https:\/\/shop.autorenwelt.de\/en\/products\/exact-efficient-and-computationally-feasible-inference-von-max-moldovan","provider":"Autorenwelt Shop","version":"1.0","type":"link"}