{"product_id":"endocrine-disruptors-a-major-medical-challenge-von-hoang-vu-dang","title":"Endocrine Disruptors - A Major Medical Challenge","description":"\u003cp\u003eExposure to Endocrine Disruptors (EDs) with estrogen  like activities during late pregnancy can induce  temporal and specific alterations in gene expression  profiles in the uteri of dams and neonates, most  likely reflecting the temporal susceptibility of the  reproductive tract to estrogenic EDs in which some  estrogen responsive expressed markedly in the uterus  of neonates. In addition, results from our  experiments demonstrate the involvement of various  signaling pathways in response to E2 and EDs in  vitro and in vivo. These EDs may trigger the  induction of CaBP-9k, a useful biomarker for  screening the estrogenicity of EDs, via an estrogen  receptor mediated pathways in animal and cellular  models. Furthermore, non-genomic pathways appear to  be involved in the induction of CaBP-9k expression  by estrogen or estrogenic compounds. Taken together,  these results indicated that both genomic and non- genomic actions are required to induce and modulate  an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within  minutes of exposure, whereas genomic responses are  delayed and require at least several hours to become  established.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843370233\"\u003e\u003ch3\u003eAn Impact of Endocrine Disruptors on Endocrine System: their Estrogenic Mechanism in In vitro and In vivo Models\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843370233","offer_id":39470004142173,"sku":"9783843370233","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f2491fd0-68a1-491e-9d70-543f335e5ba1.jpg?v=1769494368","url":"https:\/\/shop.autorenwelt.de\/en\/products\/endocrine-disruptors-a-major-medical-challenge-von-hoang-vu-dang","provider":"Autorenwelt Shop","version":"1.0","type":"link"}