{"product_id":"emerging-concepts-targeting-immune-checkpoints-in-cancer-and-autoimmunity-von-akihiko-yoshimura-hrsg","title":"Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity","description":"\n                                \n                \u003cp\u003eThis volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.\u003c\/p\u003e\n                                  \n                \n                \u003cp\u003eWritten by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.\u003c\/p\u003e\n                            \n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783319886848\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783319689289\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783319886848","offer_id":39420922101853,"sku":"9783319886848","price":192.59,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9783319689289","offer_id":28570956234845,"sku":"9783319689289","price":192.59,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c9657274-8bb3-4721-8636-fafd5af4d333.jpg?v=1777956664","url":"https:\/\/shop.autorenwelt.de\/en\/products\/emerging-concepts-targeting-immune-checkpoints-in-cancer-and-autoimmunity-von-akihiko-yoshimura-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}