{"product_id":"crossing-over-in-the-hla-region-von-aida-charfi","title":"Crossing over in the HLA region","description":"\u003cp\u003eBone marrow transplants are the treatment of choice for many malignant and non-malignant diseases, such as leukemia, bone marrow aplasia and immune deficiency. In Tunisia, only allogeneic or allograft transplants are performed between a recipient and an HLA-identical donor. Such geno-identical donors are found in the siblings of patients who are candidates for BM transplants. Donors are first selected on the basis of histocompatibility class I (HLA-A and B) by serology. This is followed by PCR-SSP or PCR-SSO for HLA class II typing of the recipient and any compatible donor. Given that all the HLA typing kits we use are of low resolution, a microsatellite screening approach has been developed. HLA typing is completed by genotyping a panel of 4 microsatellites covering the entire HLA region. The study of haplotype segregation using this panel in the various family members of a candidate for OM transplantation enabled us to highlight genetic or CO recombinations in the HLA region.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786206517955\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786206517955","offer_id":47155726385477,"sku":"9786206517955","price":43.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/529e3531-fe46-4a06-8c01-3150471799bc.jpg?v=1758780413","url":"https:\/\/shop.autorenwelt.de\/en\/products\/crossing-over-in-the-hla-region-von-aida-charfi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}