{"product_id":"contribution-de-la-galectine-9-aux-interactions-hote-tumeur-von-klibi-jihene","title":"Contribution de la galectine 9 aux interactions hôte-tumeur","description":"\u003cp\u003eNasopharyngeal carcinomas (NPC) are human epithelial  tumors constantly associated with the Epstein-Barr  virus. However it was known that these cells were  producing in vitro exosomes carrying the galectin 9  protein. Galectin 9 is an agonist of the Tim-3  receptor, a pro-apoptotic receptor carried by the  mature CD4 + Th1 lymphocytes. Our data show that NPC  exosomes carrying galectin 9 behave as agonists of  the Tim-3 receptor. They are selectively detected in  the plasma of xenografted mice or patients with NPC.  In vitro they induce massive apoptosis of cells  derived from CD4 + Th1 lymphocyte clones expressing  Tim-3 and used as a model of cellular targets. This  effect is inhibited by pre-incubating either the  target cells with an anti-Tim-3 blocking antibody or  the exosomes with an anti-galectin 9 antibody.  Overall, our work suggests that NPC exosomes  carrying galectin 9 play an important role as a  factor of immunosuppression in NPC patients. Patient  treatment with anti-galectin 9 antibodies might be  beneficial in combination with some protocols of  adoptive immunotherapy.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786131544248\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786131544248","offer_id":40148578369629,"sku":"9786131544248","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/0ca959de-2539-4403-bda2-aae1f9ae3cd4.jpg?v=1758089329","url":"https:\/\/shop.autorenwelt.de\/en\/products\/contribution-de-la-galectine-9-aux-interactions-hote-tumeur-von-klibi-jihene","provider":"Autorenwelt Shop","version":"1.0","type":"link"}