{"product_id":"chlamydia-pneumoniae-lung-infection-in-two-inbred-mouse-strains-von-chengming-wang","title":"Chlamydia pneumoniae Lung Infection in Two Inbred Mouse Strains","description":"\u003cp\u003eInfections with Chlamydia pneumoniae have been  associated with chronic inflammatory diseases, but  the influences of multiple factors are not well  understood. A multivariate experimental design  investigated the major factors that influence  disease, chlamydial lung burden, and transcript  levels: i) host genetics, ii) pre-challenge immunity, iii) time after challenge infection, iv) dietary protein content, v) dietary antioxidant content. The combined effects of mouse strain, immune status, and time after challenge inoculation resulted in opposite outcomes for lung disease and elimination of C. pneumoniae, while dietary protein and antioxidant content had little overall influence. A simple best-fit partial least square regression model using day-3 Tim3, GATA3, and arginase 2 transcript concentrations predicted 85% of the day-10 disease and 72% of the day-10 C. pneumoniae lung load. This book has elucidated general mechanisms of chlamydial pathogenesis, and clearly supports the concept that host-dependent levels of early Th1 and Th2 responses, and their balance, significantly correlated with  late disease and pathogen load of C. pneumoniae lung  infections.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838350912\"\u003e\u003ch3\u003eMultivariate analysis of Chlamydia pneumoniae lung infection in A\/J and C57BL\/6 mice\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838350912","offer_id":39498961715293,"sku":"9783838350912","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/ad09fa55-7524-4f96-bf73-034dd2814e0e.jpg?v=1758346052","url":"https:\/\/shop.autorenwelt.de\/en\/products\/chlamydia-pneumoniae-lung-infection-in-two-inbred-mouse-strains-von-chengming-wang","provider":"Autorenwelt Shop","version":"1.0","type":"link"}