{"product_id":"chemokines-and-skin-von-undefined","title":"Chemokines and Skin","description":"\u003cp\u003eThe accumulation of white blood cells is a hallmark of inflammation. The penetra­ tion through the vessel walls and the infiltration around the inflammatory stimulus is a complex process which involves active adherence and directed migration of the inflammatory cells. Chemotactic factors stimulate both adherence and migration. Technical tools such as the Boyden chamber [1] made it possible to study leukocyte migration in vitro. This technique allows differentiation between migration direct­ ed towards a chemotactic stimulus and non-directed migration. Until a decade ago only two naturally occurring molecules had been clearly iden­ tified as potent chemotactic attractants of neutrophilic granulocytes. They were the split product of the fifth complement component C5a [2] and the arachidonic acid metabolite leukotriene B4 [3]. In 1986, a novel human monocyte-derived chemo­ taxin attracting neutrophilic granulocytes with a similar potency was found [4]. This report was quickly confirmed by several groups [5-8]. The new factor was purified, cloned and sequenced [9, 10]. The term \"interleukin 8\" (IL-8) replaced the various names proposed previously [4-8]. Sequence data revealed that IL-8 belonged to a large family of chemotactic cytokines, now called \"chemokines\" [11]. Four subfamilies were distinguished on the basis of the number and position of the first cysteine residues. They are desig­ nated accordingly as C, CC, CXC and CX C chemokines [11-13]. The number of 3 human chemokines identified so far is close to 40 [11-13].\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783034897976\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783034897976","offer_id":49592316232005,"sku":"9783034897976","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/7b42b9a9-485f-4c62-9936-aaac56e702e2.jpg?v=1773207231","url":"https:\/\/shop.autorenwelt.de\/en\/products\/chemokines-and-skin-von-undefined","provider":"Autorenwelt Shop","version":"1.0","type":"link"}