{"product_id":"cefixime-trihydrate-sustained-release-matrix-tablet-von-parth-patel-und-kinjal-patel","title":"Cefixime Trihydrate Sustained Release Matrix Tablet","description":"\u003cp\u003eThe present work aims to study effect of diff. viscosity grade of HPMC on cefixime trihydrate sustained release matrix tablet with a view to prolong drug release in vivo \u0026amp; reduce frequency of dosing. Cefixime Trihydrate is an orally active third generation cephalosporin and active against Gram+ve as well as Gram -ve bacteria. It has plasma half-life of 3-4 hrs. The Sustained release matrix tablets were prepared by wet granulation method using diff. grade of HPMC, Lactose, MCC \u0026amp; PVP K-30. The granules were subjected to pre-compression \u0026amp; post-compression parameters and they were in the acceptable limits. The in vitro drug release from HPMC matrices in accordance with its diff. proportion and viscosity grade was HPMC K-100M \u0026gt; K-15M \u0026gt; K-4M with ratio of (1, 1.5, 2) individually in formulation F1-F9 and (0.5, 0.75, 1) ratio in F10-F12. Drug-excipient interaction was performed by DSC \u0026amp; FTIR; results were shown that there was no interaction. After 3 months stability study at 400C\/75% RH, formulations found to be stable. So as the viscosity and proportion of HPMC increases release rate from sustained release cefixime trihydrate matrix tablet decreases.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639515534\"\u003e\u003ch3\u003eTo study the effect of different viscosity grade of HPMC on Cefixime Trihydrate sustained Release Matrix Tablet\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639515534","offer_id":39484101591133,"sku":"9783639515534","price":59.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9b7e0607-5771-49e1-91c0-42b15df670e1.jpg?v=1770447508","url":"https:\/\/shop.autorenwelt.de\/en\/products\/cefixime-trihydrate-sustained-release-matrix-tablet-von-parth-patel-und-kinjal-patel","provider":"Autorenwelt Shop","version":"1.0","type":"link"}