{"product_id":"causes-and-consequences-of-genomic-instability-in-prostate-cancer-von-anthony-joshua","title":"Causes and Consequences of Genomic Instability in Prostate Cancer","description":"\u003cp\u003eThe evolution of prostate cancer from normal epithelium via  prostatic intraepithelial neoplasia to invasive carcinoma is  characterised by particular genomic abnormalities that are  predominantly generated in the preneoplastic phase. Telomere  dysfunction is thought to be a major contributor to the cause of  these alterations. This thesis clarifies the association of telomere  dysfunction with markers of genomic instability such as  abnormalities of chromosome 8, PTEN deletions and TMPRSSS2-ERG  aberrations as well as HPIN outcome. A previously unrecognised  association between the telomere length in various types of prostatic  epithelia and adjacent stroma is defined, suggesting evidence of a  micro-environmental field effect. Therefore there are important  avenues for further research to determine the nature of barriers to  the evolution of prostatic carcinogenesis such as oncogene- and  telomere-induced senescence that may be exploited for therapeutic  gain. These understandings may also help tailor management for  prostate cancer such as risk stratification for men with HPIN and the  use of targeted agents.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838351759\"\u003e\u003ch3\u003eAn exploration of the mechanisms and impact of genomic aberrations in prostatic carcinogenesis\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838351759","offer_id":39499090198621,"sku":"9783838351759","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f23f6544-4046-4847-bac1-8741491fb252.jpg?v=1757742930","url":"https:\/\/shop.autorenwelt.de\/en\/products\/causes-and-consequences-of-genomic-instability-in-prostate-cancer-von-anthony-joshua","provider":"Autorenwelt Shop","version":"1.0","type":"link"}