{"product_id":"biological-cell-membrane-dynamics-induced-by-electric-pulses-von-zhen-ji","title":"Biological cell membrane dynamics induced by electric pulses","description":"\u003cp\u003eRevision with unchanged content. Electroporation has been found to be a very effective approach to introduce  low and high molecular weight molecules such as drugs, hormones, proteins,  DNA, and chromosomes into biological cells. Although electroporation has  been under investigation for long time, the dynamic formation and resealing  of pores is still not completely understood. In this work, we first  computationally analyzed the electric field dosimetry for a Gigahertz Transverse  Electromagnetic chamber. We found that this exposure method  suffered from undesirable field polarity oscillations. Using a novel microfabricated  microcuvette and pulse delivering system, we conducted a series of  experimental studies of electroporation of HL-60 cells. Theoretical models  were also employed to describe the mechanisms for pore formation and  development of a spherical (HL-60) cell. A locally constrained surface tension  model was proposed to represent the cytoskeleton and anchor proteins in the  cell membrane and was observed to provide a plausible explanation for  experimental evidence of long-lived pores. Also, transport mechanisms of  small charged molecules associated with electroporation were analyzed.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639432251\"\u003e\u003ch3\u003eBackground, Experiment and Modeling\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639432251","offer_id":39489769832541,"sku":"9783639432251","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/60afd449-48c8-46a6-a907-77341d580ea2.jpg?v=1770702464","url":"https:\/\/shop.autorenwelt.de\/en\/products\/biological-cell-membrane-dynamics-induced-by-electric-pulses-von-zhen-ji","provider":"Autorenwelt Shop","version":"1.0","type":"link"}