{"product_id":"biochemical-characterization-of-dystrophin-spectrin-type-repeats-von-ismaeel-muhamed","title":"Biochemical Characterization of Dystrophin Spectrin Type Repeats","description":"\u003cp\u003eThe dystrophin gene and its association with  dystrophies is a prime factor to study the spectrin  type repeats (STR) of dystrophin. There are 24 triple  helical rods of Dystrophin STRs having four  flexible hinges. The exon skipping and tissue  specifity of the dystrophin isoforms make its  function diverse. The deletion of STRs and mutations  causes instability of the protein leading to  diseases.   This work studies the stability of spectrin type  repeat, which would identify the roles and probably  understand the function of individual spectrin repeat  in diseases.  The repeats are subjected to urea and temperature  and the helical stability is measured. Structure  prediction methods were worked on d1617 dystrophin  spectrin double repeat to predict its structure which  resulted in 4 angstrom resolution. The crystal  structure could not be solved with low resolution but  deduced the crystal conditions of face centered  orthorhombic F222 space group for d1617. The STR stability and structure is important in  medicine and gene therapy, which would aid in  complementing against absent repeats or frame  shift mutation in dystrophies and also aid in drug  development.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843360814\"\u003e\u003ch3\u003eBiochemical and Biophysical analysis of Dystrophin Spectrin Type Repeats with emphasis on structure  prediction.\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843360814","offer_id":39497174024285,"sku":"9783843360814","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/836fb6fd-27f9-49c0-8f2a-eb4c295583b0.jpg?v=1773296920","url":"https:\/\/shop.autorenwelt.de\/en\/products\/biochemical-characterization-of-dystrophin-spectrin-type-repeats-von-ismaeel-muhamed","provider":"Autorenwelt Shop","version":"1.0","type":"link"}