{"product_id":"anti-cancer-activities-of-some-bacterial-polysaccharides-derivatives-von-azza-el-amir","title":"Anti-cancer activities of some bacterial polysaccharides derivatives","description":"\u003cp\u003eBSL could be a promising anti-initiation agent in vitro through inhibition of CYP 1A mediated carcinogen metabolism and induction of GST activity as well as GSH level. BSL also possesses anti-inflammatory activity through its capacity to enhance macrophage proliferation rate and its ability to inhibit stimulated NO, TNF-¿ and COX-2 levels. Besides preventing tumor promotion, BSL showed inhibitory activity toward DNA fragmentation and cytotoxic property against Hep-G2 tumor cell line as anti-progression properties. In vivo administration of BSL before and after DEN induction showed inhibitory activity toward HDAC and lipid peroxidation which induced by DEN. Also, BSL modulates GST-P expression which upregulated with DEN injection. It resulted in a significant increase in GST activity and GSH level. It downregulates TNF-¿ level and induced apoptosis. Anti-progression properties of BSL represented by its inhibitory activities to DNA fragmentation and VEGF where PDGF level was unaffected. Furthermore, . Garlic showed an induction in GST activity and GSH level and it increases TNF-¿ and decreases VEGF level.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659637919\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659637919","offer_id":39434390208605,"sku":"9783659637919","price":61.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/88f12814-c4a4-4a18-bc1f-04ff59f68403.jpg?v=1770443925","url":"https:\/\/shop.autorenwelt.de\/en\/products\/anti-cancer-activities-of-some-bacterial-polysaccharides-derivatives-von-azza-el-amir","provider":"Autorenwelt Shop","version":"1.0","type":"link"}