{"product_id":"androgen-receptor-modulation-in-prostate-cancer-von-peyman-tavassoli","title":"Androgen Receptor Modulation in Prostate Cancer","description":"\u003cp\u003eThere is considerable evidence to suggest that  progression of prostate cancers to castration- resistant is due to inappropriate activation of the  androgen receptor (AR) and hence, the AR is a good  target for the treatment of this disease. In this  study we used two approaches to investigate AR  activation and inhibition. We developed high-throughput, non-invasive, cell- based screening assays to rapidly and biologically  assess factors that modulate prostate cancer growth  and affect AR activity. Using these assays, we found  that differentiated osteoblast-like condition media  enhanced prostate cancer cell growth, but not AR  activity. In addition, we applied this system to  screen compounds, selected through in silico  approaches against a crucial pocket on the AR  protein. The application of our in silico tools and  our cell based screening assay resulted in  identification of 17 compounds out of 4 millions  that can inhibit AR activity. Importantly, some of  these compounds are more potent than bicalutamide,  which is one of the most potent antiandrogen drugs  currently used to treat patients with metastatic  prostate cancer.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838352473\"\u003e\u003ch3\u003eBasics, Concepts, Methods\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838352473","offer_id":39486522359901,"sku":"9783838352473","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/ab1c3a4f-8616-46c0-b705-581394e1c4c0.jpg?v=1775622939","url":"https:\/\/shop.autorenwelt.de\/en\/products\/androgen-receptor-modulation-in-prostate-cancer-von-peyman-tavassoli","provider":"Autorenwelt Shop","version":"1.0","type":"link"}