{"product_id":"analytics-of-dissolution-testing-of-products-containing-nanosized-drugs-with-a-view-to-predicting-plasma-profiles-von-daniel-junemann","title":"Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles","description":"\u003cp\u003eThe oral bioavailability of a drug substance is strongly related to its aqueous solubility.\u003c\/p\u003e\u003cp\u003eOnly complete dissolution during the GI-passage can maintain an optimal\u003c\/p\u003e\u003cp\u003ebioavailability. Poor aqueous drug solubility results, according to the Nernst-Brunner\u003c\/p\u003e\u003cp\u003eequation into a slow dissolution rate, sometimes too slow for complete dissolution in\u003c\/p\u003e\u003cp\u003ethe GI tract. The dissolution rate increases with decreasing particle size and therefore\u003c\/p\u003e\u003cp\u003eincreasing surface area of the drug particles. In consequence,, micronization of the\u003c\/p\u003e\u003cp\u003edrug is applied to increase oral bioavailability, but often meets with modest success.\u003c\/p\u003e\u003cp\u003eRecently developed techniques were applied to decrease the particle size into the\u003c\/p\u003e\u003cp\u003enanometer range. For some substances, pharmacokinetic parameters could be\u003c\/p\u003e\u003cp\u003einfluenced decisively, e.g. the obviation of a food effect for the drugs aprepitant and\u003c\/p\u003e\u003cp\u003efenofibrate.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783954040001\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783954040001","offer_id":40592944791645,"sku":"9783954040001","price":30.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3fd86bf6-a8a2-4f4f-919c-8a1d43edd693.jpg?v=1780379151","url":"https:\/\/shop.autorenwelt.de\/en\/products\/analytics-of-dissolution-testing-of-products-containing-nanosized-drugs-with-a-view-to-predicting-plasma-profiles-von-daniel-junemann","provider":"Autorenwelt Shop","version":"1.0","type":"link"}