{"product_id":"a-silent-threat-exploring-new-therapies-for-abdominal-aortic-aneurysms-von-mackil","title":"A Silent Threat: Exploring New Therapies for Abdominal Aortic Aneurysms","description":"Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function [16]. It is a fibril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disulfide bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, fibrin and integrins facilitating matrix organization and cell–matrix interactions [18]. For example, fibronectin serves as a template for proper collagen fibrillogenesis by forming a fibril network engaged by cell surface integrins [16]. Cellular traction force causes FN to be stretched several times over its resting length [18]. As a result of such stretching, cryptic integrin-binding sites within the FN molecule is exposed resulting in pleiotropic changes in cellular behavior [18]. Hence FN acts as an extracellular mechano-regulator in addition to its role in cell migration during development. Studies have also shown the implication of FN in cardiovascular diseases and tumor metastasis\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783384280077\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783384280077","offer_id":49706679501125,"sku":"9783384280077","price":29.45,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/06ba5d98-4d9c-4238-bb59-ecaa4aec1c81.jpg?v=1776489844","url":"https:\/\/shop.autorenwelt.de\/en\/products\/a-silent-threat-exploring-new-therapies-for-abdominal-aortic-aneurysms-von-mackil","provider":"Autorenwelt Shop","version":"1.0","type":"link"}